By J. L. Burton MD BSc FRCP, B. J. L. Burton MA MRCP
A favored and hugely revered ebook which all started the AIDS. it is a list-type revision ebook which supplies the basic proof in an simply assimilable shape.
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Extra info for Aids to Undergraduate Medicine, Sixth Edition
Neoplastic cells show marked nuclear pleomorphism and numerous mitotic figures, many of the atypical are identified 5. Smaller basaloid cells and squamous differentiation may be present 3 2 5 4 4 Sebaceous carcinoma Histological differential 1. Basal cell carcinoma: • Smaller cells with more basophilic nuclei and smaller cytoplasm which is not vacuolated • Less atypia • Cells are more uniform 2. indd 42 1 Other features: • Pagetoid spread to the epidermis is seen in numerous cases • EMA (epithelial membrane antigen) and adipophilin immunoperoxidase staining can be used to confirm sebaceous differentiation • None 1 Sebaceoma 42 15/06/2015 16:05 Sweat Gland Neoplasms • Benign neoplasms Apocrine adenoma Epidemiology • Rare Introduction Apocrine adenoma is a benign neoplasm which clinically presents as a smooth nonspecific nodules or papules and histologically as apocrine epithelium in either tubular or papillary patterns.
Cribriform and tubular areas 4. Abundant basophilic mucin in cysts Other features: • Perineural infiltration • Slow-growing mass invading dermis and subcutaneous tissue 4 • Typically found on scalp and chest area • High incidence of local recurrence • Perineural involvement and distant me- 3 tastases in later stages of disease Special studies • ACC is immunoreactive with epithelial membrane antigen (EMA) and carcinoembryonic antigen 1 Adenoid cystic carcinoma 2 Adenoid cystic carcinoma Histological differential 1.
No epidermal connection 3. Vascular stroma 4. A heavy diffuse lymphocytic infiltrate 1,2 4 • It has either eccrine or apocrine differentiation • Presents usually as a solitary dermal or subcutaneous papule or nodule, 1–2 cm in diameter, in a variety of hair bearing locations • Nodules are usually tender and maybe painful • Color may be reddish-brown or bluish • Can simulate a vascular lesion • Diagnosis may not be clear by clinical examination and a biopsy is usually warranted 3 Spiradenoma Histological differential 1.