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By F Benedetti; Christoph Stein; et al

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J Neurophysiol 67:1562–1573 Papapoutian A, Peier AM, Story GM, Viswanath V (2003) ThermoTRP channels and beyond: mechanisms of temperature sensation. Nat Rev Neurosci 4:529–539 Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A (2002) A TRP channel that senses cold stimuli and menthol. Cell 108:705–715 Polgár E, Gray S, Riddell JS, Todd AJ (2004) Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model.

2 Opioid Receptors . . . . . . Molecular Biology . . . . . . Structural Features of Opioid Receptors Extracellular Loops . . . . . . Transmembrane Domains . . . . C-Terminal Tail . . . . . . . Signal Transduction . . . . . . Opioid Tolerance . . . . . . . In Vitro . . . . . . . . . In Vivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

3 Opioid Receptor Ligands and Sites of Action . Endogenous Ligands . . . . . . . Exogenous Ligands . . . . . . . . Sites of Action . . . . . . . . . Supraspinal and Spinal Sites . . . . . Peripheral Sites . . . . . . . . . Peripheral Opioid Receptors and Inflammation .

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